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Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
Source: NeuroReport 2008 Jan;19(2):221-224.
Author: Foland LC, Altshuler LL, Sugar CA, Lee AD, Leow AD, Townsend J, Narr KL, Asuncion DM, Toga AW & Thompson PM
PubMed ID: 18185112
Abstract:
Previous structural neuroimaging studies of bipolar disorder have reported con£icting ¢ndings in limbic structures.Medication heterogeneity of patient samples may have contributed to these inconsistencies. Using structuralmagnetic resonance imaging we assessedwhether lithium treatmentwas associatedwith di¡erences in amygdala and hippocampal volumes in a sample of bipolar adults. A total of 49 magnetic resonance imaging scans were collected from patients who were currently treated with or without lithium. Amygdala and hippocampal volumes were analyzed using tensor-based morphometry. Statistical between-group comparisons of deformation maps showed that patients treated with lithium exhibited signi¢cantly increased volumes of the amygdala and hippocampus compared with patients who were not taking lithium.Our ¢ndings may help to explain previous inconsistencies in the bipolar literature.
Source: NeuroReport 2008 Jan;19(2):221-224.
Author: Foland LC, Altshuler LL, Sugar CA, Lee AD, Leow AD, Townsend J, Narr KL, Asuncion DM, Toga AW & Thompson PM
PubMed ID: 18185112
Abstract:
Previous structural neuroimaging studies of bipolar disorder have reported con£icting ¢ndings in limbic structures.Medication heterogeneity of patient samples may have contributed to these inconsistencies. Using structuralmagnetic resonance imaging we assessedwhether lithium treatmentwas associatedwith di¡erences in amygdala and hippocampal volumes in a sample of bipolar adults. A total of 49 magnetic resonance imaging scans were collected from patients who were currently treated with or without lithium. Amygdala and hippocampal volumes were analyzed using tensor-based morphometry. Statistical between-group comparisons of deformation maps showed that patients treated with lithium exhibited signi¢cantly increased volumes of the amygdala and hippocampus compared with patients who were not taking lithium.Our ¢ndings may help to explain previous inconsistencies in the bipolar literature.