Publications
Text queries can be conducted by Author, Title, or Keyword.
Estimation of local cerebral protein synthesis rates with L-[1-
11C]leucine and PET: methods, model, and results in animals and humans
Source: J Cereb Blood Flow Metab 1989 Aug;9(4):446-460.
Author: Hawkins RA;Huang SC;Barrio JR;Keen RE;Feng D;Mazziotta JC;Phelps ME
PubMed ID: 2786885
Abstract:
We have estimated the cerebral protein synthesis rates (CPSR) in a series of normal human volunteers and monkeys using L-[1-11C]leucine and positron emission tomography (PET) using a three-compartment model. The model structure, consisting of a tissue precursor, metabolite, and protein compartment, was validated with biochemical assay data obtained in rat studies. The CPSR values estimated in human hemispheres of about 0.5 nmol/min/g agree well with hemispheric estimates in monkeys. The sampling requirements (input function and scanning sequence) for accurate estimates of model parameters were investigated in a series of computer simulation studies
Source: J Cereb Blood Flow Metab 1989 Aug;9(4):446-460.
Author: Hawkins RA;Huang SC;Barrio JR;Keen RE;Feng D;Mazziotta JC;Phelps ME
PubMed ID: 2786885
Abstract:
We have estimated the cerebral protein synthesis rates (CPSR) in a series of normal human volunteers and monkeys using L-[1-11C]leucine and positron emission tomography (PET) using a three-compartment model. The model structure, consisting of a tissue precursor, metabolite, and protein compartment, was validated with biochemical assay data obtained in rat studies. The CPSR values estimated in human hemispheres of about 0.5 nmol/min/g agree well with hemispheric estimates in monkeys. The sampling requirements (input function and scanning sequence) for accurate estimates of model parameters were investigated in a series of computer simulation studies