Publications
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The C15O2 build-up technique to measure regional cerebral blood
flow and volume of distribution of water
Source: J Cereb Blood Flow Metab 1989 Aug;9(4):461-470.
Author: Lammertsma AA;Frackowiak RS;Hoffman JM;Huang SC;Weinberg IN;Dahlbom M;MacDonald NS;Hoffman EJ;Mazziotta JC;Heather JD
PubMed ID: 2786886
Abstract:
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O- labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques
Source: J Cereb Blood Flow Metab 1989 Aug;9(4):461-470.
Author: Lammertsma AA;Frackowiak RS;Hoffman JM;Huang SC;Weinberg IN;Dahlbom M;MacDonald NS;Hoffman EJ;Mazziotta JC;Heather JD
PubMed ID: 2786886
Abstract:
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O- labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques