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Three Dimensional Reconstruction
Source: 1990 Aug;:189-210.
Author: Toga AW.
Abstract:
The brain is multidimensional. If we are to study it, measure it, and appreciate it in all of its structural and functional complexities, we must be able to visualize it in accurate 3-space. Methods used to examine the brain must sample it, and serial sectioning is the most common technique. At best, these samples provide clear and informative views of two-dimensional (2-D) sections. The third dimension is lost. With practice, of course, we develop accurate skills of cognitive reassembly to comprehend the original 3-space. However, our understanding is based on preconceived notions and may not be sensitive to individual idiosyncrosies. To make matters worse, a whole new class of images derived from studies of functional anatomy often transcends traditional ways of thinking about anatomic spatial relationships. The following discussion of 3D reconstruction encompasses all the theory and methods necessary for reassembly, data organization, synthesis, and display. The goal of these methods is to provide the viewer with more useful information about the brain than otherwise would be possible. In neurobiology, as in many things, the whole is greather than the sum of the parts.
Source: 1990 Aug;:189-210.
Author: Toga AW.
Abstract:
The brain is multidimensional. If we are to study it, measure it, and appreciate it in all of its structural and functional complexities, we must be able to visualize it in accurate 3-space. Methods used to examine the brain must sample it, and serial sectioning is the most common technique. At best, these samples provide clear and informative views of two-dimensional (2-D) sections. The third dimension is lost. With practice, of course, we develop accurate skills of cognitive reassembly to comprehend the original 3-space. However, our understanding is based on preconceived notions and may not be sensitive to individual idiosyncrosies. To make matters worse, a whole new class of images derived from studies of functional anatomy often transcends traditional ways of thinking about anatomic spatial relationships. The following discussion of 3D reconstruction encompasses all the theory and methods necessary for reassembly, data organization, synthesis, and display. The goal of these methods is to provide the viewer with more useful information about the brain than otherwise would be possible. In neurobiology, as in many things, the whole is greather than the sum of the parts.