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Dynamics of gray matter loss in Alzheimer’s disease
Source: Journal of Neuroscience 2003 Feb;23(3):994-1005.
Author: Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, Herman D, Hong MS, Dittmer SS, Doddress DM, Toga AW.
PubMed ID: 12574429
Abstract:
We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer’s Disease (AD). The loss pattern was visualized in 4D as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere > right), and correlated with progressively declining cognitive status (p<0.0006). Novel brain mapping methods visualized dynamic patterns of atrophy in 52 high-resolution MRI scans of 12 AD patients (age: 68.4±1.9 yrs.) and 14 elderly matched controls (age: 71.4±0.9 yrs.), scanned longitudinally (two scans; interscan interval: 2.1±0.4 years). A cortical pattern matching technique encoded changes in brain shape and tissue distribution across subjects and time. Cortical atrophy occurred in a well-defined sequence as the disease progressed, mirroring the sequence of neurofibrillary tangle accumulation seen cross-sectionally at autopsy. Advancing deficits were visualized as dynamic maps that change over time. Frontal regions, spared early in the disease, showed pervasive deficits later (>15% loss). The maps distinguished different phases of AD, and differentiated AD from normal aging. Local gray matter loss rates (5.3%±2.3%/year in AD versus 0.9±0.9%/year in controls) were faster in the left hemisphere (p<0.029) than the right. Transient barriers to disease progression appeared at limbic/frontal boundaries. This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly and dementia populations.
Source: Journal of Neuroscience 2003 Feb;23(3):994-1005.
Author: Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, Herman D, Hong MS, Dittmer SS, Doddress DM, Toga AW.
PubMed ID: 12574429
Abstract:
We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer’s Disease (AD). The loss pattern was visualized in 4D as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere > right), and correlated with progressively declining cognitive status (p<0.0006). Novel brain mapping methods visualized dynamic patterns of atrophy in 52 high-resolution MRI scans of 12 AD patients (age: 68.4±1.9 yrs.) and 14 elderly matched controls (age: 71.4±0.9 yrs.), scanned longitudinally (two scans; interscan interval: 2.1±0.4 years). A cortical pattern matching technique encoded changes in brain shape and tissue distribution across subjects and time. Cortical atrophy occurred in a well-defined sequence as the disease progressed, mirroring the sequence of neurofibrillary tangle accumulation seen cross-sectionally at autopsy. Advancing deficits were visualized as dynamic maps that change over time. Frontal regions, spared early in the disease, showed pervasive deficits later (>15% loss). The maps distinguished different phases of AD, and differentiated AD from normal aging. Local gray matter loss rates (5.3%±2.3%/year in AD versus 0.9±0.9%/year in controls) were faster in the left hemisphere (p<0.029) than the right. Transient barriers to disease progression appeared at limbic/frontal boundaries. This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly and dementia populations.