Publications
Text queries can be conducted by Author, Title, or Keyword.
Cortical Change in Alzheimer's Disease Detected with a disease-specific population-based brain atlas
Disease-Specific Population-Based Brain Atlas
Source: Cerebral Cortex 2001 Jan;11(1):1-16.
Author: Thompson PM, Mega MS, Woods RP, Zoumalan CI, Lindshield CJ, Blanton RE, Moussai J, Holmes CJ, Cummings JL, Toga AW.
PubMed ID: 11113031
Abstract:
We report the first, detailed, population-based maps of early gray matter loss across the human cortex in Alzheimer’s Disease (AD), detected with a new strategy for resolving group-specific patterns of cortical organization and gray matter distribution. Methods. High-resolution 3D SPGR (spoiled GRASS) MRI volumes were acquired from 26 subjects with mild to moderate AD (age: 75.8±1.7 yrs.; MMSE score: 20.0±0.9), and 20 normal elderly controls (72.4±1.3 yrs.) matched for age, sex, handedness and educational level. 84 anatomical models per brain were created for all 46 subjects (16 deep sulcal, callosal and hippocampal surfaces, all major cortical sulci, Sylvian fissures, 14 ventricular regions, and 36 gyral and 3D cytoarchitectural boundaries). High-dimensional elastic mappings were computed to control for gyral pattern variations, generating a disease-specific average anatomical representation with highly-resolved structures in their mean spatial locations. Statistical variations in cortical patterning, asymmetry, gray matter distribution and average gray matter loss were encoded as a non-stationary Gaussian random tensor field, and used to detect disease-specific differences. Results. An overall pattern of left greater than right hemisphere gray matter loss displayed sharp contrasts between heteromodal and idiotypic cortex. The principal directions of normal cortical variability exhibited clear boundaries, demarcating cortical zones appearing at different embryonic phases. Once these variations were controlled, population-based features of average tissue loss, cortical organization and asymmetry emerged. Pervasive tissue loss in temporo-parietal association cortices was visualized, and found to be considerably greater than in sensorimotor and occipital cortices, consistent with cognitive, metabolic and histologic patterns in early AD.
Source: Cerebral Cortex 2001 Jan;11(1):1-16.
Author: Thompson PM, Mega MS, Woods RP, Zoumalan CI, Lindshield CJ, Blanton RE, Moussai J, Holmes CJ, Cummings JL, Toga AW.
PubMed ID: 11113031
Abstract:
We report the first, detailed, population-based maps of early gray matter loss across the human cortex in Alzheimer’s Disease (AD), detected with a new strategy for resolving group-specific patterns of cortical organization and gray matter distribution. Methods. High-resolution 3D SPGR (spoiled GRASS) MRI volumes were acquired from 26 subjects with mild to moderate AD (age: 75.8±1.7 yrs.; MMSE score: 20.0±0.9), and 20 normal elderly controls (72.4±1.3 yrs.) matched for age, sex, handedness and educational level. 84 anatomical models per brain were created for all 46 subjects (16 deep sulcal, callosal and hippocampal surfaces, all major cortical sulci, Sylvian fissures, 14 ventricular regions, and 36 gyral and 3D cytoarchitectural boundaries). High-dimensional elastic mappings were computed to control for gyral pattern variations, generating a disease-specific average anatomical representation with highly-resolved structures in their mean spatial locations. Statistical variations in cortical patterning, asymmetry, gray matter distribution and average gray matter loss were encoded as a non-stationary Gaussian random tensor field, and used to detect disease-specific differences. Results. An overall pattern of left greater than right hemisphere gray matter loss displayed sharp contrasts between heteromodal and idiotypic cortex. The principal directions of normal cortical variability exhibited clear boundaries, demarcating cortical zones appearing at different embryonic phases. Once these variations were controlled, population-based features of average tissue loss, cortical organization and asymmetry emerged. Pervasive tissue loss in temporo-parietal association cortices was visualized, and found to be considerably greater than in sensorimotor and occipital cortices, consistent with cognitive, metabolic and histologic patterns in early AD.