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Hippocampal atrophy in persons with age associated memory impairment: Volumetry within a common space
Source: Psychosomatic Medicine 2002 Jun;64(3):487-492.
Author: Mega MS, Small GW, Xu ML, Felix J, Manese M, Tran NP, Dailey JI, Ercoli LM, Bookheimer SY, Toga AW.
PubMed ID: 12021422
Abstract:
Objective: To determine if patients with mild cognitive impairment (MCI) have focal hippocampal atrophy compared to cognitively intact elderly. Methods: High resolution three dimensional (3D) brain magnetic resonance imaging (MRI) was performed on 20 nondemented subjects: 10 had MCI, and 10 were cognitively intact elderly. Each scan was aligned in the Talairach coordinate space and re-sliced every 1 mm perpendicular to the long axis of the hippocampus, which was manually outlined with volumes determined for the hippocampal head and body. Results: Subject groups were similar in age, sex ratios, and education achievement. The MCI group had significantly lower mean scores on the immediate and delayed logical memory task of the Wechsler Memory Scale (p<0.01), and significantly lower volumes for the right hippocampus and hippocampal head (p=0.02). Conclusion: The right hippocampal head may be the earliest site to reflected significant volume loss in MCI.
Source: Psychosomatic Medicine 2002 Jun;64(3):487-492.
Author: Mega MS, Small GW, Xu ML, Felix J, Manese M, Tran NP, Dailey JI, Ercoli LM, Bookheimer SY, Toga AW.
PubMed ID: 12021422
Abstract:
Objective: To determine if patients with mild cognitive impairment (MCI) have focal hippocampal atrophy compared to cognitively intact elderly. Methods: High resolution three dimensional (3D) brain magnetic resonance imaging (MRI) was performed on 20 nondemented subjects: 10 had MCI, and 10 were cognitively intact elderly. Each scan was aligned in the Talairach coordinate space and re-sliced every 1 mm perpendicular to the long axis of the hippocampus, which was manually outlined with volumes determined for the hippocampal head and body. Results: Subject groups were similar in age, sex ratios, and education achievement. The MCI group had significantly lower mean scores on the immediate and delayed logical memory task of the Wechsler Memory Scale (p<0.01), and significantly lower volumes for the right hippocampus and hippocampal head (p=0.02). Conclusion: The right hippocampal head may be the earliest site to reflected significant volume loss in MCI.