Publications
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Imaging and functional localization for brain tumors
Source: Clinical Neurosurgery 1992;39:475-481.
Author: Black KL, Mazziotta JC, Toga AW.
PubMed ID: 1458754
Abstract:
Despite high-resolution magnetic resonance imaging (MRI), computed tomography (CT) scanners and positron emission tomography (PET), the extent of tumor infiltration in the brain cannot be defined by current imaging modalities. Failure of these techniques can be attributed in part, to their reliance only on differences in tissue attenuation characteristics, breakdown of the blood-brain barrier (BBB) to contrast agents, mass effect or changes in glucose or amino acid transport. An ability to image tumors with a ligand that binds specifically to tumor cells and that readily would cross the intact BBB might significantly improve tumor resolution in the brain and allow better identification of the outermost margin of tumor cells. Although surgery alone is not curative for most primary brain tumors because of extensive microscopic infiltration, cytoreduction probably will continue to play an important role in future strategies to manage these tumors. The ability to bring tumor localization directly to the operating room, therefore, is critical. Equally important, because these tumors frequently infiltrate into eloquent areas of the brain, is the need for technology to identify and preserve functional brain. The chapter reviews some novel strategies that might improve the ability to localize tumors peroperatively, localize tumors intraoperatively, and intraoperatively localize functional brain in relation to tumors.
Source: Clinical Neurosurgery 1992;39:475-481.
Author: Black KL, Mazziotta JC, Toga AW.
PubMed ID: 1458754
Abstract:
Despite high-resolution magnetic resonance imaging (MRI), computed tomography (CT) scanners and positron emission tomography (PET), the extent of tumor infiltration in the brain cannot be defined by current imaging modalities. Failure of these techniques can be attributed in part, to their reliance only on differences in tissue attenuation characteristics, breakdown of the blood-brain barrier (BBB) to contrast agents, mass effect or changes in glucose or amino acid transport. An ability to image tumors with a ligand that binds specifically to tumor cells and that readily would cross the intact BBB might significantly improve tumor resolution in the brain and allow better identification of the outermost margin of tumor cells. Although surgery alone is not curative for most primary brain tumors because of extensive microscopic infiltration, cytoreduction probably will continue to play an important role in future strategies to manage these tumors. The ability to bring tumor localization directly to the operating room, therefore, is critical. Equally important, because these tumors frequently infiltrate into eloquent areas of the brain, is the need for technology to identify and preserve functional brain. The chapter reviews some novel strategies that might improve the ability to localize tumors peroperatively, localize tumors intraoperatively, and intraoperatively localize functional brain in relation to tumors.