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Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment.
Source: Annals of Neurology 2009 May;65(4):414-423.
Author: Judy Pa, Adam Boxer, Linda L. Chao, Adam Gazzaley, Katie Freeman, Joel Kramer, Bruce L. Miller, Michael W. Weiner, John Neuhaus, Julene K. Johnson
PubMed ID: 19399879
Abstract:
Objective Subgroups of mild cognitive impairment (MCI) have been proposed, but few studies have investigated the non-amnestic, single-domain subgroup of MCI. The goal of the study was to compare clinical and neuroimaging characteristics of two single domain MCI subgroups: amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Methods We compared the cognitive, functional, behavioral and brain imaging characteristics of patients with aMCI (n=26), dMCI (n=32) and age- and education-matched controls (n=36) using analysis of variance and chi-squared tests. We used voxel-based morphometry (VBM) to examine group differences in brain MRI atrophy patterns. Results Patients with dMCI had significantly lower scores on the majority of executive function tests, increased behavioral symptoms, and left prefrontal cortex atrophy on MRI when compared to controls. In contrast, patients with aMCI had significantly lower scores on tests of memory and a pattern of atrophy including bilateral hippocampi and entorhinal cortex, right inferior parietal cortex, and posterior cingulate gyrus when compared to controls. Interpretation Overall, the clinical and neuroimaging findings provide support for two distinct single-domain subgroups of MCI, one involving executive function and the other involving memory. The brain imaging differences suggest that the two MCI subgroups have distinct patterns of brain atrophy.
Source: Annals of Neurology 2009 May;65(4):414-423.
Author: Judy Pa, Adam Boxer, Linda L. Chao, Adam Gazzaley, Katie Freeman, Joel Kramer, Bruce L. Miller, Michael W. Weiner, John Neuhaus, Julene K. Johnson
PubMed ID: 19399879
Abstract:
Objective Subgroups of mild cognitive impairment (MCI) have been proposed, but few studies have investigated the non-amnestic, single-domain subgroup of MCI. The goal of the study was to compare clinical and neuroimaging characteristics of two single domain MCI subgroups: amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Methods We compared the cognitive, functional, behavioral and brain imaging characteristics of patients with aMCI (n=26), dMCI (n=32) and age- and education-matched controls (n=36) using analysis of variance and chi-squared tests. We used voxel-based morphometry (VBM) to examine group differences in brain MRI atrophy patterns. Results Patients with dMCI had significantly lower scores on the majority of executive function tests, increased behavioral symptoms, and left prefrontal cortex atrophy on MRI when compared to controls. In contrast, patients with aMCI had significantly lower scores on tests of memory and a pattern of atrophy including bilateral hippocampi and entorhinal cortex, right inferior parietal cortex, and posterior cingulate gyrus when compared to controls. Interpretation Overall, the clinical and neuroimaging findings provide support for two distinct single-domain subgroups of MCI, one involving executive function and the other involving memory. The brain imaging differences suggest that the two MCI subgroups have distinct patterns of brain atrophy.