Publications
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Vascular plasticity and cognition during normal aging and dementia.
Source: JAMA Neurology 2015 May;72(5):495-496.
Author: Axel Montagne, PhD, Judy Pa, PhD, and Berislav V. Zlokovic, MD, PhD
PubMed ID: 25751405
Abstract:
Functional neurovascular changes reflecting alterations in brain function and cognition and/or originating primarily from abnormalities localized to the cerebrovascular system have been described in many neurological disorders and during normal brain aging. However, the relationship between vascular and neuronal dysfunction, and how they relate to each other and contribute to cognitive impairment and dementia due to Alzheimer’s disease (AD), vascular cognitive impairment and dementia (VCID), and/or other neurological disorders, still remains controversial1,2. An obvious place to look for neurovascular and cognitive changes is in the hippocampus, a region involved with learning and memory that is particularly susceptible to changes in oxygen and blood supply and is damaged early in AD.
Source: JAMA Neurology 2015 May;72(5):495-496.
Author: Axel Montagne, PhD, Judy Pa, PhD, and Berislav V. Zlokovic, MD, PhD
PubMed ID: 25751405
Abstract:
Functional neurovascular changes reflecting alterations in brain function and cognition and/or originating primarily from abnormalities localized to the cerebrovascular system have been described in many neurological disorders and during normal brain aging. However, the relationship between vascular and neuronal dysfunction, and how they relate to each other and contribute to cognitive impairment and dementia due to Alzheimer’s disease (AD), vascular cognitive impairment and dementia (VCID), and/or other neurological disorders, still remains controversial1,2. An obvious place to look for neurovascular and cognitive changes is in the hippocampus, a region involved with learning and memory that is particularly susceptible to changes in oxygen and blood supply and is damaged early in AD.